STUDIES ON TRIMETHYLAMINE OXIDE
نویسندگان
چکیده
منابع مشابه
Trimethylamine oxide excretion rates in elasmobranchs.
GOLDSTEIN, LEON, AND PAUL J. PALATT. Trimethylamine oxide excretion rates in elasmobranchs. Am. J. Physiol. 227(6) : 1268-1272. 1974.-The purpose of this study was to investigate the relationship between rates of excretion and rates of biosynthesis of trimethylamine oxide (TMAO) in elasmobranchs. TMAO excretion rates were estimated in four elasmobranchs previously shown to differ in their abili...
متن کاملThe biosynthesis of trimethylamine-N-oxide.
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in vitro. The additional requirement for redu...
متن کاملStructural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm), a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is responsible for converting TMA to TMAO. However, the molecular mechanism of TMA oxygenation by Tmm has not been explained. Here, we determined t...
متن کاملEffect of trimethylamine and its homologues on renal conservation of trimethylamine oxide by the spiny dogfish, Squalus acanthias.
COHEN, JULIUS J., MARCUS A. KRUPP, CHARLES A. CHIDSEY III AND CHARLES I. BILTZ. Effect of trimethylamine and its homologues on renal conservation of brimethylamine oxide by the spiny dogjsh, Squalus acanthias, Am. J. Physiol. I g6( I): 93-99 I g5g.-In renal clearance experiments with dogfish, trimethylamine HCL (TMA) d a ministration (i.m.) results in a large increase in trimethylamine oxide (O...
متن کاملTrimethylamine N-Oxide: The Good, the Bad and the Unknown
Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing effects of urea. Plasma level of TMAO is determined by a number of factors including diet, gut microbial flora and liver flavin monooxygenase...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1945
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)43150-x